How therapists' interpersonal behaviour is perceived by their patients and close others: A longitudinal and cross-situational study

Due to their predictive abilities, therapist interpersonal behaviour is of great relevance for psychotherapy. However, there is a lack of knowledge about its stability inside but also outside of the therapy room within and between therapists. The current study investigates interpersonal behaviour of trainee therapists (N = 20) as perceived by four patients each suffering from generalized anxiety disorder and three closely related persons of every therapist (close others). Investigating repeated measures, four patients per therapist completed the Impact Message Inventory (IMI; Kiesler, 1987) three times over the course of their cognitive behavioural therapy. Furthermore, the IMI was completed by three close others at one assessment time. Therapist interpersonal behaviour was perceived as more friendly and less submissive when evaluated by close others compared to patients. Using a multilevel approach, our results indicate that therapists' interpersonal behaviour was perceived considerably stable across patients and over the course of treatment, and there is considerable uniformity of the IMI evaluations in respect to the particular subscales within and between therapists. Our results highlight the potential similarities of observer-based habitual therapists' interpersonal behaviour inside and outside of the therapy room. Keywords: impact message inventory; perceptions of therapists; therapists' effects; therapists' interpersonal behaviour; therapy researc

Estimations of Population Density for Selected Periods Between the Neolithic and AD 1800

We describe a combination of methods applied to obtain reliable estimations of population density using archaeological data. The combination is based on a hierarchical model of scale levels. The necessary data and methods used to obtain the results are chosen so as to define transfer functions from one scale level to another. We apply our method to data sets from western Germany that cover early Neolithic, Iron Age, Roman, and Merovingian times as well as historical data from AD 1800. Error margins and natural and historical variability are discussed. Our results for nonstate societies are always lower than conventional estimations compiled from the literature, and we discuss the reasons for this finding. At the end, we compare the calculated local and global population densities with other estimations from different parts of the world

Associations Between Vocal Arousal and Dyadic Coping During Couple Interactions After a Stress Induction

It is well known that although relationship external stressors can harm couples, dyadic coping behavior can buffer the negative effects of stress. Thus far, however, less is known about how vocally encoded stress (i.e., f$_{0}$) might affect the stress-coping process in couples during an interaction. Therefore, the goal of the current study was to compare two different stress hypotheses (i.e., paraverbal communication stress hypothesis and emotional resonance hypothesis). We observed 187 mixed-gender couples (N = 374 participants) interacting naturally after an experimental stress induction (Trier Social Stress Test), for which couples were randomly allocated into three groups (women stressed, men stressed, and both stressed). Results of a multi-group actor-partner interdependence mediation model (APIMeM) show that either the paraverbal communication stress hypothesis or the emotional resonance hypothesis could be confirmed, depending on whether the man, the woman, or both partners were stressed

Synthesis of the HIV-Proteinase Inhibitor Saquinavir: A Challenge for Process Research

The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir, a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield

Automatic Analysis of Sewer Pipes Based on Unrolled Monocular Fisheye Images

The task of detecting and classifying damages in sewer pipes offers an important application area for computer vision algorithms. This paper describes a system, which is capable of accomplishing this task solely based on low quality and severely compressed fisheye images from a pipe inspection robot. Relying on robust image features, we estimate camera poses, model the image lighting, and exploit this information to generate high quality cylindrical unwraps of the pipes' surfaces.Based on the generated images, we apply semantic labeling based on deep convolutional neural networks to detect and classify defects as well as structural elements.Comment: Published in: 2018 IEEE Winter Conference on Applications of Computer Vision (WACV

Stress Crossover in Intimate Relationships: A New Framework for Studying Dynamic Co-Regulation Patterns in Dyadic Interactions

It has been demonstrated that stress, experienced outside of a relationship, can spill into a relationship and cross over during interactions from one partner to the other. However, the mechanism of how stress cross over in real-time between partners is still unknown. To overcome this limitation, we invited 189 couples (N = 378 individuals) for two interactions and stressed either the man, the woman, or both partners between the interactions with a standardized stress-induction procedure. Vocally-encoded emotional arousal (i.e., fundamental frequency, indexed as fo) was extracted from both partners in 25,834 talk turns. Dynamical systems modeling revealed four patterns of dynamic influence prior to stress induction, which started to erode after the stress induction. This demonstrates that the initially unstressed mates become stressed during the behavioral exchange and stress crosses over from the unstressed partner to the stressed mates, interfering with their ability to down-regulate stress

Buwchitin:A Ruminal Peptide with Antimicrobial Potential against <i>Enterococcus faecalis</i>

Antimicrobial peptides (AMPs) are gaining popularity as alternatives for treatment of bacterial infections and recent advances in omics technologies provide new platforms for AMP discovery. We sought to determine the antibacterial activity of a novel antimicrobial peptide, buwchitin, against Enterococcus faecalis. Buwchitin was identified from a rumen bacterial metagenome library, cloned, expressed and purified. The antimicrobial activity of the recombinant peptide was assessed using a broth microdilution susceptibility assay to determine the peptide's killing kinetics against selected bacterial strains. The killing mechanism of buwchitin was investigated further by monitoring its ability to cause membrane depolarization (diSC3(5) method) and morphological changes in E. faecalis cells. Transmission electron micrographs of buwchitin treated E. faecalis cells showed intact outer membranes with blebbing, but no major damaging effects and cell morphology changes. Buwchitin had negligible cytotoxicity against defibrinated sheep erythrocytes. Although no significant membrane leakage and depolarization was observed, buwchitin at minimum inhibitory concentration (MIC) was bacteriostatic against E. faecalis cells and inhibited growth in vitro by 70% when compared to untreated cells. These findings suggest that buwchitin, a rumen derived peptide, has potential for antimicrobial activity against E. faecalispublishersversionPeer reviewe

Role of Pelvic Lymph Node Resection in Vulvar Squamous Cell Cancer:A Subset Analysis of the AGO-CaRE-1 Study

Background: As the population at risk for pelvic nodal involvement remains poorly described, the role of pelvic lymphadenectomy (LAE) in vulvar squamous cell cancer (VSCC) has been a matter of discussion for decades. Methods: In the AGO-CaRE-1 study, 1618 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB or higher primary VSCC treated at 29 centers in Germany between 1998 and 2008 were documented. In this analysis, only patients with pelvic LAE (n = 70) were analyzed with regard to prognosis and correlation between inguinal and pelvic lymph node involvement. Results: The majority of patients had T1b/T2 tumors (n = 47; 67.1%), with a median diameter of 40 mm (2–240 mm); 54/70 patients (77.1%) who received pelvic LAE had positive groin nodes. For 42 of these 54 patients, the number of affected groin nodes had been documented as a median of 3; 14/42 (33.3%) of these patients had histologically confirmed pelvic nodal metastases (median number of affected pelvic nodes 3 [1–12]). In these 14 patients, the median number of affected groin nodes was 7 (1–30), with a groin metastases median maximum diameter of 42.5 mm (12–50). Receiver operating characteristic analysis showed an area under the curve of 0.85, with 83.3% sensitivity and 92.6% specificity for the prediction of pelvic involvement in cases of six or more positive groin nodes. No cases of pelvic nodal involvement without groin metastases were observed. Prognosis in cases of pelvic metastasis was poor, with a median progression-free survival of only 12.5 months. Conclusion: For the majority of node-positive patients with VSCC, pelvic nodal staging appears unnecessary since a relevant risk for pelvic nodal involvement only seems to be present in highly node-positive disease